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. 2017 Sep 28;45(20):11782–11799. doi: 10.1093/nar/gkx871

Figure 4.

Figure 4.

3E10 inhibits RAD51 binding to DNA and RAD51-mediated strand exchange. (A) Scheme of RAD51 DNA binding assay performed with pre-incubation of RAD51 and 2XMBP-scFv proteins. (B) Representative assay results. (C) Quantification of RAD51 bound to DNA for each condition. (D) A strand exchange assay was performed with pre-incubation of RAD51 and 2XMBP-scFv proteins. (E) Representative assay results. (F) Quantification of RAD51 mediated strand exchange for each condition. Error bars represent the SEM; ****P < 0.0001, ***P < 0.001, **P < 0.01 and *P < 0.05 by unpaired t-test.