Table 4.

Significant Predictors for Different Clinical Outcomes After Regression Analyses and Bonferroni Correction

	Positive Blood Cultures by GN		Relapse				Gvhd Within 30 Days
			Univariate Analysis		Multivariate Analysis
Risk Factor	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	OR (95% CI)
Disease status			.019	5.633 (2.067–15.353)	.006	6.214 (1.900–20.323)
Disease Risk Index			.019	7.174 (2.170–23.719)	.042	4.503 (1.255–16.166)
Shannon index ≤4 at T0	n.s.
Enterobacteriaceae >5% at T0	.021	6.577 (2.246–19.255)
Lachnospiraceae ≤10% at T0	n.s.
Ruminococcaceae ≤10% at T0	n.s.
Shannon ≤1.3% at T1			n.s.				.038	7.833 (2.141–28.658)
Staphylococcaceae >40% at T1			n.s.				n.s.

Analyses were performed with Cox regression for the following outcomes: positive blood cultures by all causes, by gram-negative and by gram-positive, severe sepsis or septic shock, relapse. Binary logistic regression was performed for GvHD within 30 or 100 days. Only outcomes with significant markers are listed in the table, and confidence intervals are reported only for significant variables after Bonferroni family-wise correction. For further details, see the supplementary material.

Abbreviations: CI, confidence interval; GN, gram-negative; GvHD, graft-vs-host disease; HR, hazard ratio; OR, odds ratio; n.s., not significant.