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. 2017 Sep 18;45(20):11941–11953. doi: 10.1093/nar/gkx808

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Possible feedback control of 5MP1 transcription. Pearson correlation between ATF4 mRNA levels (A) or cMYC mRNA (B) and 5MP1, 5MP2 and eIF5 mRNA levels. Correlation coefficients were calculated in 10 different cancers. Significant correlations are demarcated with an asterisk (P < 0.05). (C) A model of cMyc-5MP1-ATF4 pathway involved in oncogenic transcription. Dotted arrows indicate transcriptional control, whereas straight arrows and stop bar denote translational control. (D) Correlation between 5MP1 or eIF5 expression with the prognosis of breast or lung cancer patients (see Supplemental text for details).