Figure 6.

Prediction results on another dataset of influenza symptom from GSE30550 for validation. (A) The detected marker genes (recovered genes) from GSE30550 analysis, and the Common Sx gene from GSE52428 analysis, and the 22-gene marker from our previous study. (B) The ROC of prediction. (C) The prediction curves of individuals. The red circle points the clinically diagnosed infection-time for the corresponding subject, and the green star mark indicates the predicted infection-time by our prediction cut-off. Clearly, we correctly predicted all of the symptom cases except S5 before the clinical symptom, and the accuracy of the prediction is about 90%. Although the tipping point of subject S5 predicted by iENA coincides with the first clinical symptom point at 45 h, we count S5 as an incorrect prediction in this paper.