Table 1. Characteristics at last paediatric care visit of patients transferred to adult care.
| Characteristic | Total (N=644) |
Born in UK/Ireland (N=245) |
Born abroad* (N=399) |
P |
|---|---|---|---|---|
| n (%) or median [IQR] | ||||
| Female sex | 343 (53) | 131 (53) | 212 (53) | 0.93 |
| Ethnicity | ||||
| Black African | 480 (75) | 140 (57) | 340 (85) | <0.0001 |
| White | 86 (13) | 64 (26) | 22 (6) | |
| Other | 78 (12) | 41 (17) | 37(9) | |
| Age at first presentation in UK (years) | 6.4 [1.8, 11.1] | 1.4 [0.1,4.3] | 9.3 [5.7,12.3] | <0.0001 |
| Calendar year of first presentation in UK | ||||
| <2000 | 364 (57) | 210 (86) | 154 (39) | <0.0001 |
| ≥2000 | 280 (43) | 35 (14) | 245 (61) | |
| Ever received ART | 575 (89) | 224 (91) | 351 (88) | |
| Characteristics at ART start (n=575) | ||||
| Age (years) | 9.6 [5.4,12.8] | 6.5 [3.0,10.7] | 10.7 [7.7,13.8] | <0.0001 |
| <5 years | 116 (24) | 81 (45) | 35 (11) | |
| CDC C stage | 127 (22) | 58 (26) | 69 (20) | 0.079 |
| CD4% for age<5 yrs (n=91, 71, 20) | 15 [8,24] | 15 [8,24] | 15 [8,22] | 0.80 |
| CD4 cell count for age ≥5 yrs (n=365, 116, 249) | 210 [91,350] | 205 [100,386] | 214 [80,330] | 0.51 |
| Viral load (log10) (n=364, 133, 231) | 4.9 [4.3,5.3] | 5.0 [4.4,5.5] | 4.8 [4.3,5.2] | 0.021 |
| Initial ART regimen | ||||
| Mono/dual NRTI | 149 (26) | 85 (36) | 64 (18) | <0.0001 |
| Triple NRTI | 22 (4) | 8 (4) | 14 (4) | |
| NNRTI+NRTI | 276 (48) | 72 (32) | 204 (58) | |
| PI+NRTI | 128 (22) | 59 (26) | 69 (20) | |
| Characteristics at transfer to adult care | ||||
| Age (years) | 17.4 [16.5,18.1] | 17.4 [16.4,18.3] | 17.3 [16.5,18.1] | 0.62 |
| CDC C stage | 171 (27) | 75 (31) | 96 (24) | 0.68 |
| CD4 cell count, cells/mm3 | 444 [280,643] | 412 [250,640] | 456 [289,648] | 0.15 |
| ≤200 | 101 (16) | 50 (20) | 51 (13) | |
| 201-350 | 122 (21) | 47 (19) | 86 (22) | |
| 351-500 | 142 (22) | 56 (23) | 86 (21) | |
| >500 | 268 (42) | 92 (38) | 176 (44) | |
| Viral load (log10) (n=643) | 2.0 [1.7,3.8] | 2.0 [1.7,4.0] | 2.0 [1.7,3.7] | 0.19 |
| VL <400 copies if on ART at transfer (n=481) | 357/481 (74) | 131/178 (74) | 226/303 (75) | |
| ART status | <0.0001 | |||
| Naïve | 69 (11) | 21 (9) | 48 (12) | |
| On initial cART | 167 (26) | 43 (18) | 124 (31) | |
| On subsequent cART | 284 (44) | 114 (47) | 170 (43) | |
| On mono/dual ART | 39 (6) | 23 (9) | 16 (4) | |
| Off-ART after previous exposure | 85 (13) | 44 (18) | 41 (10) | |
| Duration since start of ART (years) (n=575) | 7.8 [4.3,12.0] | 10.8 [6.9,14.5] | 6.2 [3.4,9.8] | <0.0001 |
| Triple class exposure (n=575) | 312 (54) | 143 (64) | 169 (48) | <0.0001 |
| Calendar year of transfer | 0.52 | |||
| 2000-2002 | 21 (3) | 5 (2) | 16 (4) | |
| 2003-2005 | 68 (11) | 22 (9) | 46 (12) | |
| 2006-2008 | 126 (20) | 49 (20) | 77 (19) | |
| 2009-2011 | 226 (35) | 91 (37) | 135 (34) | |
| 2012-2014 | 203 (32) | 78 (32) | 125 (31) | |
Notes: * Includes 11 patients with unknown country of birth.