Table 2. Factors associated with immunological and virological status at transfer to adult care in ART-exposed patients.
| CD4 cell count increase |
VL<400 copies/mL |
|||||||
|---|---|---|---|---|---|---|---|---|
| Univariable Coef (95% CI) | P | Multivariable Coef (95% CI) | P | OR (95% CI) | P | aOR (95% CI) | P | |
| Constant | 505 (479, 532) | 774 (682,867) | ||||||
| Sex - female vs male | -23.3 (-76, 29) | 0.39 | 0.87 (0.6, 1.2) | 0.41 | ||||
| Born abroad vs UK/Ireland | 25.4 (-80, 29) | 0.36 | 33 (-23, 89) | 0.25 | 1.25 (0.9, 1.8) | 0.2 | 0.9 (0.5, 1.5) | 0.60 |
| Ethnicity: Black African/Other vs Caucasian | -76 (-153, 1.4) | 0.054 | 0.85 (0.5, 1.4) | 0.522 | ||||
| Characteristics at ART start | ||||||||
| Age: <5 years | 1 | 0.033 | 1 | <0.001 | 1 | 0.04 | 1 | 0.62 |
| 5 - 9 years | -46 (-118, 27) | -38 (-112,36) | 0.6 (0.4,0.9) | 0.8 (0.5,2.3) | ||||
| 10 – 14 years | -36 (-106, 33) | -79 (-156,-2) | 0.9 (0.6, 1.4) | 1.1 (0.5, 2.3) | ||||
| ≥15 years | -178 (-274, -83) | -268 (-371, -165) | 1.2 (0.6, 2.4) | 1.6 (0.6, 4.8) | ||||
| CD4 percentage, per 1% increase | 7 (4, 10) | <0.001 | 5.1 (2.4, 7.8) | <0.001 | 1.03 (1.0, 1.05) | 0.04 | 0.98 (0.94, 1.01) | 0.211 |
| Initiation on non cART vs cART | -5.8 (-68, 56) | 0.86 | 0.7 (0.4,1.0) | 0.079 | 0.8 (0.4,1.5) | 0.43 | ||
| Characteristics at transfer | ||||||||
| Age, per year increase | -9 (-27, 9) | 0.307 | 0.92 (0.8, 1.0) | 0.19 | 1.09 (0.9, 1.3) | 0.87 | ||
| CDC stage: C vs N/A/B | 19.2 (-38, 77) | 0.514 | 0.7 (0.5, 1.0) | 0.066 | 0.43 (0.2, 0.75) | 0.003 | ||
| CD4 per 100c/mm3 increase | - | - | 1.94 (1.7, 2.2) | <0.001 | 2.1 (1.8, 2.4) | <0.001 | ||
| VL per log increase | -146 (-166, -124) | <0.001 | -139 (-162, -115) | <0.001 | - | - | ||
| ART status: Initial cART | 76 (18,132) | 0.033 | 67 (7,127) | 0.09 | 2.8 (1.7, 4.5) | <0.001 | 2.2 (1.2, 4.1) | 0.04 |
| Subsequent cART | 1 | 1 | 1 | 1 | ||||
| Mono/dual ART | 35 (-64,135) | 14 (-77,104) | 0.9 (0.4, 1.8) | 0.86 (0.3, 2.2) | ||||
| Exposure to triple class ART | -77 (-130, -24) | 0.004 | -5 (-74,64) | 0.90 | 0.6 (0.4, 0.9) | 0.006 | 0.6 (0.3, 1.3) | 0.20 |
| Duration since start ART, per year increase | 6.7 (1.1, 12) | 0.019 | 11 (-2, 24) | 0.104 | 0.98 (0.94, 1.0) | 0.176 | 0.97 (0.9, 1.03) | 0.35 |
| Calendar year: 2000-2002 | -179 (-348, -9) | 0.019 | -29 (-198,139) | 0.94 | 0.06 (0.01,0.3) | 0.002 | 0.06 (0.01,0.5) | 0.021 |
| 2003-2008 | 1 | 1 | 1 | 1 | ||||
| 2009-2014 | 40 (-20, 101) | -1 (-58,57) | 0.9 (0.6,1.2) | 0.6 (0.3, 1.2) | ||||
Notes: OR; odds ratio, aOR; adjusted odds ratio. P values <0.2 are shown in bold. Shaded variables were included in the final multivariable models.