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. 2017 Jun 8;125(6):067002. doi: 10.1289/EHP347

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Three regional plots indicate ranges 0, 2, 4, 6, 8, and 10 (y-axis); positions 44.6, 44.7, 44.8, and 44.9 (x-axis); and ranges 0, 20, 40, 60, 80, and 100 in centimorgan to megabase (z-axis). — Manhattan plot of $- \log_{10}$ p-value vs. chromosomal position of each SNP from the trans-ethnic, fixed-effects meta-analysis of the $SNP \times {PM}_{10}$ interactions. The red line references the genome-wide significance threshold (p-value $< 5.0 \times 10^{- 8}$ ).