Figure 2.

Regional plots of the locus, rs1619661, identified by the trans-ethnic, fixed-effects meta-analysis of the $\text{SNP}\times {\text{PM}}_{10}$ interactions, on chromosome 10, near CXCL12. Each point represents the $-{\log }_{10}$p-value of a SNP plotted as a function of its genomic position (build 37) and the genome-wide significance threshold (p-value$<5.0\times {10}^{-8}$). One SNP reached this threshold. The color coding of all other SNPs indicated linkage disequilibrium with this lead SNP, estimated among Africans (A), Ad-mixed Americans (B), and Europeans (C) from 1000G. Recombination rates were estimated from the 1,000 Genomes Project.