Table 5.

Associations between ${\mathrm{NO}}_2$ exposure and gene expression in 16-y-old BAMSE children ($N=238$).

Probe ID	Gene	${\mathrm{NO}}_2$ during infancy			${\mathrm{NO}}_2$ at 16 y
		LogFCa	p-value	FDRbp-value	LogFCa	p-value	FDRbp-value
TC12001696.hg.1	IFNG	0.04	0.41	0.49	0.06	0.29	0.69
TC02002219.hg.1	IL1B	$-0.06$	0.30	0.42	$-0.17$	0.01	0.09
TC01003766.hg.1	IL10	0.09	0.003	0.06	0.05	0.13	0.59
TC03000870.hg.1	IL12A	0.04	0.13	0.19	0.08	0.02	0.09
TC05001997.hg.1	IL12B	0.03	0.33	0.43	0.02	0.66	0.79
TC05000640.hg.1	IL13	0.07	0.01	0.07	0.08	0.02	0.09
TC04001520.hg.1	IL2	0.05	0.13	0.19	0.004	0.93	0.93
TC05000641.hg.1	IL4	0.03	0.44	0.49	$-0.01$	0.86	0.93
TC07000137.hg.1	IL6	0.001	0.97	0.97	0.02	0.54	0.69
TC04000408.hg.1	IL8	$-0.01$	0.84	0.89	0.01	0.89	0.93
TC6_apd_hap1000036.hg.1	TNF	0.09	0.04	0.07	0.06	0.28	0.69
TC06000371.hg.1c	TNF	0.08	0.04	0.07	0.03	0.51	0.69

Note: IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.

^aResults are obtained by means of linear regression analyses and presented per $10\mathrm{\mu }\mathrm{g}/{\mathrm{m}}^3$ increase of ${\mathrm{NO}}_2$ exposure. Adjusted for child’s sex, DD asthma ever up to 16 y of age, municipality at birth, and measured cell counts. $\text{LogFC}=\text{logarithm}\text{fold}-\text{change}$ (one unit of the logFCs translates to a two-fold change in expression).

^b$\text{FDR}=\text{false}\text{discovery}\text{rate}\text{correction}\text{based}\text{on}18\text{probesets}$.

^cSeven alternatives haplotypes assemblies of this TNF probeset are available (apd, cox, dbb, mann, mcf, qbl and ssto) and bear similar log2 intensity values.