Table 4.

Summary of select studies on variation in postsurgical lumpectomy cavity before and during breast radiotherapy.

					Change in lumpectomy cavity volume
First Author, year	N	Treatment	Imaging Technique	Surgical Clips	Before RT a	During RT a	Correlated with time from surgery	Correlated with initial LC volume
Vicini, 20037	18	PBI	CT	Yes	NR	Yes	NR	NR
Weed, 20045	28	17 PBI, 11 WBI	CT	Yes	NR	Yes b	Ye s c	NR
Jacobson, 20068	20	WBI	CT	No	NR	Yes	NR	Yes
Oh, 20069	30	WBI	CT	Yes	NR	Yes	Yes c	Ye s
Kader, 20082	205	PBI	CT	No	Yes	NR	Yes c	NR
Hurkmans, 200910	10	WBI	CT	Yes	NR	Yes	Yes c	NR
Harris, 200911	11	WBI	CT, PI	Yes	Yes	Yes	NR	NR
Hepel, 200912	30	WBI	CT	Yes d	NR	Yes	Yes c	Ye s
Prendergast, 200913	36	30 WBI, 6 PBI	CT	Yes	Yes	Yes	Yes	Yes
Tersteeg, 200914	77	WBI	CT	Yes d	NR	Yes	NR	Yes
Sharma, 200915	24	WBI	CT	Yes d	NR	Yes	Yes c	NR
Flannery, 200916	43	WBI	CT	Yes d	NR	Yes	Yes	Yes
Yang, 201017	102	WBI	CT, CBCT |e	No	NR	Yes	Yes c	Ye s
Yang, 201018	19	WBI	CT, CBCT	No	NR	Yes	NR	NR
Kim, 201019	13	PBI	CT	Yes d	Yes	NR	NR	NR
Present Study	26	20 WBI, 6 PBI	CT, CBCT	Yes	Yes	Yes	Yes	Yes

^a Before RT refers to period of LC change assessment where a second imaging scan was performed before the start of RT while during RT refers to time period where a second imaging scan was performed during or at end of RT.

^b Second CT was performed just before, during or day of completion of treatment.

^c An inverse relationship was observed between time from surgery and change in LC volume.

^d Clips were used when available.

^e 10 patients underwent multiple CBCT scans during RT and data was analyzed to assess correlation between CT and CBCT scans for seroma contouring.

$\mathrm{N}=\text{number}\hspace{0.17em}\text{of}\hspace{0.17em}\text{patients}$; $\text{RT}=\text{Radiotherapy}$; $\text{LC}=\text{lumpectomy}\hspace{0.17em}\text{cavity}$; $\text{PBI}=\text{partial}\hspace{0.17em}\text{breast}\hspace{0.17em}\text{irradiation}$; $\text{CT}=\text{computed}\hspace{0.17em}\text{tomography}\hspace{0.17em}\text{scan}$; $\text{NR}=\text{not}\hspace{0.17em}\text{reported}$; $\text{WBI}=\text{whole}\hspace{0.17em}\text{breast}\hspace{0.17em}\text{irradiation}$; $\text{PI}=\text{Portal}\hspace{0.17em}\text{imaging}$; $\text{CBCT}=\text{Cone}\hspace{0.17em}\text{Beam}\hspace{0.17em}\text{CT}$.