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. 2013 Mar 4;14(2):77–89. doi: 10.1120/jacmp.v14i2.4046

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© 2013 The Authors.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Algorithm for alignment and calculation for FRE. Calculation of the transformation matrix can be done including all markers or excluding the outlier. However, the transformation is applied to all markers to calculate FRE.