Table 1. Main characteristics of 43 patients with tegumentary leishmaniasis treated with liposomal amphotericin B.
Characteristics of patients | n = 43 | |
---|---|---|
Demographics | ||
Median age, years [range] | 51 [1–86] | |
Male | 29 (67) | |
Cardiovascular comorbidities and/or diabetes | 7 (16) | |
Immunocompromised subject | 5 (12) | |
Child | 6 (14) | |
Clinical form | ||
Localized cutaneous | 32 (74) | |
Mucocutaneous | 8 (19) | |
Disseminated cutaneous | 2 (5) | |
Localized cutaneous with visceral involvement | 1 (2) | |
Area where infection was acquired | ||
Old World | 28 (65) | |
New World | 15 (35) | |
Leishmania Species (n = 35; 8 species unidentified) | ||
L. braziliensis | 11 (31) | |
L. braziliensis complex | 2 (6) | |
L. guyanensis | 1 (3) | |
L. amazonensis | 1 (3) | |
L. infantum | 9 (26) | |
L. major | 6 (17) | |
L. tropica | 3 (8) | |
L. donovani | 2 (6) | |
Clinical findings | ||
Number of lesions, median [range] | 2 [1–30] | |
Larger lesion size (millimeter), median [range] | 30 [4–200] | |
Treatment | ||
Frontline therapy with L-AmB | 30 (70) | |
Liposomal AmB cumulative dose (mg/kg), median [range] | 20 [6–56] | |
Number of infusions, median [range]a | 6 [2–14] | |
Outcome | ||
Follow-up (days), median [range] | 79 [28–803] | |
Complete healing without relapse | 19 (44) | |
Improvement | 2 (5) | |
Failure | 17 (39) | |
Relapse | 5 (12) | |
Adverse events | ||
Patients with at least one adverse event | 23 (53) | |
Treatment modification due to adverse events | 7 (16) |
L-AmB, liposomal amphotericin B. Data are n (%) unless otherwise indicated.
a this information was available for 24 patients