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. 2017 Dec 4;35(48Part A):6563–6574. doi: 10.1016/j.vaccine.2017.01.047

Table 2.

Current society guidelines for diagnosing spontaneous abortion.

ACOG ≤19 6/7 First trimester
Non-viable, intrauterine pregnancy with either an empty gestational sac or a gestational sac containing an embryo or fetus without fetal heart activity within the first 12 6/7 weeks of gestation.
Findings diagnostic of spontaneous abortion (first trimester)
Crown-rump length (CRL) of 7 mm of greater and no heartbeat
Mean sac diameter of 25 mm or greater and no embryo
Absence of embryo with heartbeat 2 weeks or more after an ultrasound that showed a gestational sac without a yolk sac
Absence of embryo with heartbeat 11 days or more after an ultrasound that showed a gestational sac with a yolk sac
Second trimester
Spontaneous pregnancy loss after the first trimester and before 20 weeks gestation
[96]



NICE/RANZCOG/RCOG Evaluation with transvaginal ultrasound
If the mean gestational sac diameter is less than 25 mm and there is no visible fetal pole then perform a second ultrasound a minimum of 7 days after the first before making a diagnosis
If the mean gestational sac diameter is 25 mm or more and there is no visible fetal pole then seek a second opinion on the viability of the pregnancy and/or perform a second ultrasound a minimum of 7 days after the first
If the CRL is less than 7 mm and there is no visible heartbeat, perform a second ultrasound a minimum of 7 days after the first before making a diagnosis, and even more scans may be needed
If the CRL is 7 mm or more and there is no visible heartbeat, then one can seek a second opinion and/or perform a second ultrasound a minimum of 7 days after the first before making a decision regarding viability of the pregnancy
Evaluation with transabdominal ultrasound
If there is no visible heartbeat when the CRL is measured then record the size of the CRL and perform a second scan a minimum of 14 days after the first scan
Serum B-HCG should not be used alone to determine the viability of a pregnancy of unknown location.
[5]



SGOC ≤23 6/7 First trimester
Mean gestational sac diameter exceeds 8 mm without a yolk sac by transvaginal ultrasound
Mean gestational sac diameter exceeds 16 mm without an embryo by transvaginal ultrasound
Gestational sac greater than 20 mm without a yolk sac by transabdominal ultrasound
Gestational sac 25 mm without an embryo by transabdominal ultrasound
No cardiac activity in an embryo greater than 5 mm by transvaginal ultrasound or 9 mm by transabdominal ultrasound
Second Trimester
All spontaneous pregnancy losses from 13 weeks of gestation until the fetus reaches viability, 24 weeks gestation
[4]