Table 4. Lethal mutants in the histone libraries.
| Category | H2A | H2B | H2A&H2B | H3a | H4a | H3&H4a |
|---|---|---|---|---|---|---|
| Lethal mutants | 15 (5.7%) | 7 (2.1%) | 22 (3.7%) | 44 (13.3%) | 36 (15.5%) | 80 (14.2%) |
| Lethal point mutations | 14 | 7 | 21 | 41 | 28 | 69 |
| Lethal residues | 9 | 7 | 16 | 32 | 20 | 52 |
| Lethal mutants with changed charge | 13 | 6 | 19 | 25 | 20 | 45 |
| Lethal mutants with charge reversal | 8 | 3 | 11 | 11 | 9 | 20 |
| Mutants with charge reversal | 29 | 36 | 65 | 44 | 32 | 76 |
| Point mutations | 241 | 275 | 516 | 275 | 202 | 477 |
| Total mutants | 265 | 327 | 592 | 330 | 232 | 562 |
a
Indicates the results from both published data (Dai et al. 2008) and this study (Table S2 in File S1).