Table 7. Numbers of significant SNPs (P-value <0.01).
CPMA | LRT-Sum with Approach 2 (overlap) | Wald-Sum with Approach 1 (overlap) | Wald-Sum with Approach 2 (overlap) | |
---|---|---|---|---|
With assumption | 47 | 57 (46) | 48 (47) | 57 (46) |
Without assumption | 52 (43) | 46 (45) | 52 (43) |
“With assumption”: assuming each SNP is already known to be significant for one trait, then testing whether there is at least one more significant association; “Without assumption”: directly testing whether there are at least two significant associations for each SNP; “Overlap”: the numbers of the significant SNPs that are also among the 47 detected ones by CPMA (“With assumption”).