FIG. 4.

ROC curves based on definitively identified metabolites and lipidomics results. AUC values of >0.9 indicate a high specificity and sensitivity of the combination of metabolites for selective identification based on different radiation quality. The six metabolites identified in urine (L-phenylalanine, N-decanoylglycine, phenylpyruvic acid, sebacic acid, xanthurenic acid and decanoylcarnitine) provide a separation of 1 Gy neutron from 1 Gy X rays with high specificity and sensitivity at both days 1 and 7 postirradiation, as demonstrated by the high arch of the curve. The serum signature, on the other hand (metabolomics and lipidomics markers), exhibited high specificity and sensitivity only on day 1, with generally low AUC levels at day 7.