TABLE 3.
Fold Changes and Trends of Serum Lipidomics Data
| Metabolite | m/z_RT | ESI and adduct | ppm error | 1 Gy neutron/Control | 1 GyX ray/Control | 1 Gy neutron/1 Gy X ray | Trend between 1 Gy exposed (neutron/X ray) | P value 1 Gy comparisons | FDR value |
|---|---|---|---|---|---|---|---|---|---|
| Day 1 | |||||||||
| Linoleic acid | 279.2330_2.47 | [M − H]− | 0.5 | −3.2 | −1.4 | −2.2 | ê | <0.001 | 0.06 |
| Docosahexanoic acid | 327.2327_2.23 | [M − H]− | 0.6 | −1.8 | −1.2 | −1.5 | ê | <0.001 | 0.08 |
| Arachidonic acid | 303.2327_2.35 | [M − H]− | 0.8 | −1.8 | −1.2 | −1.5 | ê | 0.002 | 0.11 |
| LysoPC(18:0) | 524.3714_1.99 | [M + H]+ | 0.7 | −1.3 | 1.0 | −1.4 | ê | 0.002 | 0.12 |
| LysoPC(20:1) | 550.3873_2.08 | [M + H]+ | 1.2 | −3.0 | 1.0 | −2.9 | ê | <0.001 | 0.06 |
| LysoPE(20:0) | 510.3560_1.65 | [M + H]+ | 1.2 | −1.4 | 1.0 | −1.4 | ê | <0.001 | 0.06 |
| LysoPE(22:0) | 538.3871_2.367 | [M + H]+ | 0.7 | −1.4 | 1.1 | −1.6 | ê | 0.001 | 0.10 |
| CE(18:2) | 666.6187_7.93 | [M + NH4]+ | 0.6 | −1.2 | 1.0 | −1.3 | ê | <0.001 | 0.08 |
| CE(18:3) | 664.6029_7.77 | [M + NH4]+ | 0.3 | −1.5 | 1.1 | −1.6 | ê | 0.002 | 0.11 |
| CE(20:4) | 690.6185_7.82 | [M + NH4]+ | 0.4 | −1.2 | 1.1 | −1.3 | ê | <0.001 | 0.08 |
| CE(20:5) | 688.6029_7.66 | [M + NH4]+ | 0.3 | −1.7 | 1.1 | −1.8 | ê | 0.002 | 0.11 |
| CE(22:6) | 714.6186_7.74 | [M + NH4]+ | 0.4 | −1.3 | 1.1 | −1.4 | ê | 0.005 | 0.18 |
| TG(52:1) | 878.8167_8.15 | [M + NH4]+ | 0.4 | −3.3 | −1.9 | −1.8 | ê | 0.004 | 0.17 |
| TG(52:3) | 874.7860_7.85 | [M + NH4]+ | 0.3 | −1.9 | −1.1 | −1.8 | ê | 0.004 | 0.17 |
| TG(55:3) | 916.8323_7.66 | [M + NH4]+ | 0.5 | −3.1 | −1.2 | −2.7 | ê | 0.004 | 0.17 |
| TG(56:4) | 928.8320_8.02 | [M + NH4]+ | 0.8 | −3.0 | 1.3 | −4.0 | ê | 0.004 | 0.17 |
| TG(56:6) | 924.7988_7.80 | [M + NH4]+ | 2.9 | −2.9 | 1.0 | −2.9 | ê | <0.001 | 0.09 |
| TG(56:8) | 920.7704_7.56 | [M + NH4]+ | 0.3 | −2.6 | −1.1 | −2.5 | ê | <0.001 | 0.09 |
| TG(57:3) | 944.8642_7.85 | [M + NH4]+ | 0.2 | −1.7 | −1.1 | −1.6 | ê | 0.002 | 0.11 |
| TG(57:3) | 944.8642_8.21 | [M + NH4]+ | 0.3 | −1.8 | 1.0 | −1.8 | ê | 0.004 | 0.17 |
| TG(57:4) | 942.8486_7.69 | [M + NH4]+ | 0.4 | −1.6 | 1.0 | −1.6 | ê | 0.004 | 0.17 |
| TG(58:10) | 944.7705_7.43 | [M + NH4]+ | 0.5 | −3.8 | −1.1 | −3.5 | ê | 0.003 | 0.17 |
| TG(58:10) | 927.7430_7.72 | [M + H]+ | 0.7 | −8.1 | 1.0 | −8.2 | ê | 0.004 | 0.17 |
| TG(58:3) | 958.8798_7.85 | [M + NH4]+ | 0.1 | −1.9 | −1.1 | −1.8 | ê | 0.003 | 0.16 |
| TG(58:4) | 956.8632_7.69 | [M + NH4]+ | 0.8 | −1.9 | −1.1 | −1.8 | ê | 0.005 | 0.17 |
| TG(58:8) | 948.8019_7.74 | [M + NH4]+ | 0.6 | −3.0 | −1.1 | −2.8 | ê | <0.001 | 0.08 |
| TG(58:9) | 946.7854_7.57 | [M + NH4]+ | 0.4 | −3.7 | −1.1 | −3.3 | ê | 0.002 | 0.12 |
| TG(59:3) | 972.8954_8.00 | [M + NH4]+ | 0.1 | −2.1 | −1.2 | −1.7 | ê | 0.004 | 0.17 |
| TG(61:8) | 990.8487_7.57 | [M + NH4]+ | 0.4 | –5.2 | 1.0 | –5.4 | ê | 0.001 | 0.10 |
| Day 7 | |||||||||
| Linoleic acid | 279.2330_2.47 | [M − H]− | 0.5 | −1.3 | −2.2 | 1.6 | é | 0.37 | 0.77 |
| Docosahexanoic acid | 327.2327_2.23 | [M − H]− | 0.6 | −1.1 | −1.4 | 1.3 | é | 0.28 | 0.72 |
| Arachidonic acid | 303.2327_2.35 | [M − H]− | 0.8 | −1.1 | −1.3 | 1.2 | é | 0.38 | 0.78 |
| LysoPC(18:0) | 524.3714_1.99 | [M + H]+ | 0.7 | −1.1 | −1.4 | 1.3 | é | 0.05 | 0.48 |
| LysoPC(20:1) | 550.3873_2.08 | [M + H]+ | 1.2 | 1.0 | −1.3 | 1.3 | é | 0.28 | 0.72 |
| LysoPE(20:0) | 510.3560_1.65 | [M + H]+ | 1.2 | 1.0 | −1.3 | 1.2 | é | 0.17 | 0.62 |
| LysoPE(22:0) | 538.3871_2.367 | [M + H]+ | 0.7 | −1.3 | −1.5 | 1.2 | é | 0.29 | 0.72 |
| CE(18:2) | 666.6187_7.93 | [M + NH4]+ | 0.6 | −1.2 | 1.1 | −1.3 | ê | 0.11 | 0.55 |
| CE(18:3) | 664.6029_7.77 | [M + NH4]+ | 0.3 | −1.2 | 1.2 | −1.4 | ê | 0.03 | 0.48 |
| CE(20:4) | 690.6185_7.82 | [M + NH4]+ | 0.4 | −1.1 | 1.2 | −1.3 | ê | 0.03 | 0.48 |
| CE(20:5) | 688.6029_7.66 | [M + NH4]+ | 0.3 | 1.1 | 1.2 | −1.1 | – | 0.53 | 0.86 |
| CE(22:6) | 714.6186_7.74 | [M + NH4]+ | 0.4 | −1.3 | 1.2 | −1.5 | ê | 0.03 | 0.48 |
| TG(52:1) | 878.8167_8.15 | [M + NH4]+ | 0.4 | 1.4 | 1.6 | −1.1 | – | 0.53 | 0.86 |
| TG(52:3) | 874.7860_7.85 | [M + NH4]+ | 0.3 | 1.8 | 1.3 | 1.3 | é | 0.11 | 0.54 |
| TG(55:3) | 916.8323_7.66 | [M + NH4]+ | 0.5 | 2.2 | 1.3 | 1.7 | é | 0.03 | 0.48 |
| TG(56:4) | 928.8320_8.02 | [M + NH4]+ | 0.8 | 2.1 | 2.1 | 1.0 | – | 0.93 | 0.99 |
| TG(56:6) | 924.7988_7.80 | [M + NH4]+ | 2.9 | 1.9 | 1.5 | 1.3 | é | 0.14 | 0.59 |
| TG(56:8) | 920.7704_7.56 | [M + NH4]+ | 0.3 | 1.5 | 1.3 | 1.2 | é | 0.26 | 0.71 |
| TG(57:3) | 944.8642_7.85 | [M + NH4]+ | 0.2 | 1.7 | 1.3 | 1.3 | é | 0.07 | 0.50 |
| TG(57:3) | 944.8642_8.21 | [M + NH4]+ | 0.3 | −0.6 | 1.7 | −0.7 | – | 0.003 | 0.48 |
| TG(57:4) | 942.8486_7.69 | [M + NH4]+ | 0.4 | 1.4 | 1.1 | 1.3 | é | 0.04 | 0.48 |
| TG(58:10) | 944.7705_7.43 | [M + NH4]+ | 0.5 | 1.5 | 1.4 | 1.1 | – | 0.39 | 0.78 |
| TG(58:10) | 927.7430_7.72 | [M + H]+ | 0.7 | 2.2 | 1.8 | 1.3 | é | 0.25 | 0.71 |
| TG(58:3) | 958.8798_7.85 | [M + NH4]+ | 0.1 | 1.8 | 1.3 | 1.3 | é | 0.10 | 0.53 |
| TG(58:4) | 956.8632_7.69 | [M + NH4]+ | 0.8 | 1.6 | 1.2 | 1.3 | é | 0.08 | 0.51 |
| TG(58:8) | 948.8019_7.74 | [M + NH4]+ | 0.6 | 2.0 | 1.8 | 1.1 | – | 0.52 | 0.86 |
| TG(58:9) | 946.7854_7.57 | [M + NH4]+ | 0.4 | 1.7 | 1.5 | 1.1 | – | 0.40 | 0.79 |
| TG(59:3) | 972.8954_8.00 | [M + NH4]+ | 0.1 | 1.7 | 1.7 | 1.0 | – | 0.99 | 1.00 |
| TG(61:8) | 990.8487_7.57 | [M + NH4]+ | 0.4 | 1.6 | 1.3 | 1.2 | é | 0.21 | 0.66 |