Figure 3.

Drastic Proteome Remodeling of R6/2 Mice after Disease Onset

(A and B) PCA projections (A) and PCA loadings (B) of all soluble samples reveal specific effects on the proteome driven by the genotype, age, and differential spatial expression. Data points in (B) are colored by local point density.

(C) Hierarchical clustering of protein expression over time shows substantial proteome shifts from early stages of HD onward. The two most upregulated (red and orange) or downregulated (blue and cyan) clusters are indicated.

(D) Top 20 Euclidean distance tracking of protein expression profiles similar to Pde10a over time and across brain regions; gray boxes indicate striatal expression (upper panel). Boxplots of Z-scored MaxLFQ intensities for the striatal top 20 set (lower panel). Reduced expression of all targets in R6/2 samples compared to WT.

See also Figure S2.