Table 2.

Logistic regression models

	Full Sample, including cognitively healthy and participants with MCI N=349			Subset of participants with MCI at baseline N=244
Predictor	OR	95%CI	P-value	OR	95%CI	P-value
IICV alone	2.39	(1.60, 3.56)	<0.0001	2.77	(1.72, 4.46)	<0.0001
Ratio of CSF p-tau181/Aβ42 alone	2.13	(1.52, 2.99)	<0.0001	2.16	(1.49, 3.13)	<0.0001
IICV and CSF analytes together	-	-	-	-	-	-
IICV	2.81	(1.83, 4.33)	<0.0001	3.41	(2.03, 5.73)	<0.0001
Ratio of CSF p-tau181/Aβ42	2.48	(1.72, 3.60)	<0.0001	2.63	(1.73, 4.01)	<0.0001

Notes:

Base Model included baseline age, baseline education, APOE e4 status and years of follow-up. For analyses including cognitively healthy participants and those with MCI, base model also includes baseline diagnostic status.

IICV was estimated using baseline data.

Abbreviations:

MCI: Mild Cognitive Impairment

IICV: Intra-individual cognitive variability

CSF: Cerebrospinal fluid

OR: Odd ratio

CI: Confidence Interval