Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neuropharmacology. 2017 Sep 14;128:1–10. doi: 10.1016/j.neuropharm.2017.09.019

Figure 2. Effects of LgA and ShA followed by prolonged abstinence on GLT-1A and GLT1-B levels.

Figure 2

(A, B) Behavioral data for LgA self-administration; (E, F) behavioral data for ShA self-administration, each followed by 45 days of withdrawal. (C, D) Relative GLT-1A and GLT-1B mRNA levels in the NAc, PL, and BLA after following 45 days of withdrawal from LgA self-administration. LgA cocaine self-administration and 45 days of withdrawal significantly decreases GLT-1A gene expression in the NAc and BLA (C), and significantly decreases GLT-1B gene expression in the PL (D). (G, H) Relative GLT-1A (G) and GLT-1B (H) mRNA levels in the NAc following 45 days of withdrawal from ShA self-administration. ShA self-administration and 45 days of withdrawal does not change GLT-1A or GLT-1B mRNA levels in the NAc, in contrast to LgA. *p < 0.05. +Significant difference between day 2 and day 3 of self-administration (p < 0.05).