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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neuropharmacology. 2017 Sep 21;128:33–42. doi: 10.1016/j.neuropharm.2017.09.029

Table 1.

Summary of experiments and results

Figures and Experimental Description Summary of Results
Figure 1
Measurement of phasic DA combined with intraoral infusion (Section 2.4).
I.o. infusion of 10% sucrose or 0.32% saccharin, but not 0.005% menthol nor water, increases phasic DA release in the NAc core.
Figures 24
Combined i.o. and i.v. self-administration training and behavior using long training regimen (Section 2.5).
Combined i.o. infusion of sucrose or saccharin with i.v. nicotine elevates self-administration compared to i.o. water or menthol combined with i.v. nicotine.
Combined i.o. sucrose plus i.v. nicotine leads to decreased self-administration compared to i.v. nicotine alone.
Figure 5
Progressive ratio test (Section 2.6) one day after long-training regimen. Rats used were the same as in Figures 24.
No differences in sucrose, menthol, nor saccharin in breakpoint.
Figure 6
Conditioned reinforcement test (Section 2.7) after receiving short training regimen (Section 2.5)
Conditioned reinforcement for saccharin nor menthol were altered by nicotine pairings compared to saline pairings.
Figure 7
Two-bottle choice (Section 2.8)
Menthol or saccharin increase oral consumption of nicotine.