TABLE 2.

Exposure effects of ART and depression on 5-year risk of mortality estimated among 885 ART-naïve women enrolled in the Women’s Interagency HIV Study (WIHS)

	Parametric g-formula
	5-year Mortality Risk	Risk Difference	Risk Ratio	Hazard Ratio
No ART, always depressive symptoms	23.2 (16.9, 29.4)	0.	1.	1.
No ART, never depressive symptoms	10.9 (6.5, 15.2)	−12.3 (−19.7, −4.9)	0.47 (0.37, 0.59)	0.50 (0.28, 0.89)
Immediate ART, always depressive symptoms	12.4 (6.7, 18.0)	−10.8 (−18.7, −2.9)	0.53 (0.40, 0.71)	0.44 (0.24, 0.75)
Immediate ART, never depressive symptoms	7.1 (3.8, 10.5)	−16.0 (−23.2, −8.9)	0.31 (0.26, 0.37)	0.28 (0.15, 0.52)
No ART	18.6 (14.0, 23.1)	0.	1.	1.
Immediate ART	9.0 (6.3, 11.8)	−9.6 (−14.9, −4.3)	0.49 (0.33, 0.72)	0.46 (0.30, 0.71)
Always depressive symptoms	16.4 (12.5, 20.3)	0.	1.	1.
Never depressive symptoms	9.4 (6.3, 12.6)	−7.0 (−12.0, −2.0)	0.57 (0.38, 0.87)	0.55 (0.35, 0.86)
	Inverse probability weighted marginal structural model
No ART, always depressive symptoms	25.0 (9.6, 40.4)	0.	1.	1.
No ART, never depressive symptoms	12.1 (5.1, 19.2)	−12.8 (−29.8, 4.2)	0.49 (0.21, 1.13)	0.45 (0.19, 1.05)
Immediate ART, always depressive symptoms	11.1 (5.8, 16.3)	−13.9 (−29.8, 2.0)	0.44 (0.21, 0.92)	0.39 (0.17, 0.89)
Immediate ART, never depressive symptoms	4.7 (2.0, 7.5)	−20.2 (−36.0, −4.4)	0.19 (0.08, 0.45)	0.17 (0.07, 0.42)
No ART	17.5 (11.7, 23.3)	0.	1.	1.
Immediate ART	8.2 (5.4, 11.1)	−9.3 (−15.6, −2.9)	0.47 (0.29, 0.76)	0.45 (027, 0.74)
Always depressive symptoms	17.7 (12.7, 22.6)	0.	1.	1.
Never depressive symptoms	8.4 (5.1, 11.7)	−9.3 (−15.5, −3.0)	0.48 (0.28, 0.80)	0.46 (0.27, 0.78)