Figure 5.

Propafenone suppresses tumor growth in vivo. Nude mice bearing KYSE270-derived xenografts were intraperitoneally injected with either propafenone (10 mg/kg or 20 mg/kg) or vehicle every other day (n = 7 per group). A. Left, images of tumors; Right, tumor curves showed that propafenone exerted a significantly inhibitory effect on the growth of tumor xenografts. B. Immunohistochemical analysis of the Ki-67 proliferative index and CD31-based MVD. C. Expression levels of Bcl-xL, Bcl-2 and Bax in tumors from mice treated with propafenone or vehicle were detected by Western blot. D. Comparison of the body weight of nude mice during the experimental period. E. Representative images of liver, kidney and lungs stained with hematoxylin and eosin (H&E). Bars, SD; *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with the control group.