Bone micro-architecture analysis by micro-CT on Day 28 after tumor cell injection of legs with the tumor. Tumors were induced by intra-osseous (A-D) or intra-muscular paratibial (E-H) injection. Tridimensional reconstructions with lateral, anterior, medial and posterior view (A, E). Axial mid-diaphyseal view (B, F), frontal view (C, G), and sagittal view (D, H).