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Histological analysis of necrosis (as a percentage of tumor area), cell proliferation with IHC Ki67 labeling (expressed as a proliferation index), vascularization with IHC CD146 labeling, and the rate of apoptosis with IHC caspase 3 labeling. Thresholds of significance: *: [0.05; 0.01 [, **: [0.01; 0.001 [, ***: ≤ 0.001.
