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. 2017 Nov 15;9(11):4821–4835.

Figure 3.

Figure 3

CXCR4 deletion attenuated colitis and inflammatory signs in DSS induced ulcerative colitis (UC) mice. A. Wild type (WT) mice showed no signs of colitis and inflammation. B. DSS-induced UC mice (DSS) showed signs of colitis with marked infiltration of inflammatory cells into the submucosa of the colon. C. CXCR4 knockout mice (CXCR4-/-) showed no signs of colitis and inflammation. D. CXCR4-/- mice treated with DSS (CXCR4-/- +DSS) showed attenuated degree of infiltration of inflammatory cells and signs of colitis. E. Histological scores. F. Plasma levels of SDF-1α. *P<0.05 vs. WT. #P<0.05 vs. DSS.