Figure 7.

Inhibition of JNK MAPK pathway reversed the inhibited activity of PCS by SDF-1α in colon mucosal MVECs. (A) The mRNA expression levels of Endothelial protein C receptor (EPCR) and (B) thrombomodulin (TM). (C) Protein expression of EPCR and (D) TM. (E) Luciferase assays revealed that c-Jun regulated EPCR by binding to its promoter. The activity of (F) protein C (PC), (G) protein S (PS) and (H) activated PC (APC). *P<0.05 vs. controls. #P<0.05 vs. SDF-1α. Results were obtained from at least three independent experiments performed in triplicate.