Figure 5.

MiR-145 attenuates hypoxia-induced cardiomyocyte apoptosis and mitochondrial dysfunction in vitro. A. MiR-145 expression was decreased in hypoxia-treated cells. B. Cell apoptosis was measured by FITC-conjugated Annexin V and PI assay. C. The MMP was assessed by cationic dye JC-1. D. The levels of cytochrome c in mitochondria and cytosol were assessed. Data are presented as the mean ± standard deviation. Student’s t-test was used to analyze significant differences. *P<0.05 vs. normoxia cells, #P<0.05 vs. miR-NC cells, ^P<0.05 vs. miR-145 cells.