Fig. 5.

P2X7R/PanX1 antagonism reduces overstretch injury-induced vascular apoptosis in rat aorta. a Quantitative analysis of TUNEL assay (n = 5). NS, non-stretched; S, stretched. b Representative images of TUNEL staining of rat aorta. Green, TUNEL-positive cells; red, vWF-positive cells. Boxed region enlarged to show TUNEL-positive endothelial (open arrows), medial cell (closed arrows), and adventitial (asterisk) nuclei. Scale bar = 200 μm. c Caspase activity in TNFα–treated A7r5 cells with or without BB FCF pretreatment (n = 5). *p < 0.05