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. 2017 Sep 20;13(4):591–600. doi: 10.1007/s11302-017-9586-z

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Effects of Up₄A on coronary flow and cardiac function in atherosclerosis. Shown are Up₄A concentration responses (10⁻⁸−10⁻⁵ M) in isolated hearts of wild-type (WT) (n = 6), ApoE knockout (KO) (n = 4), and ApoE KO + high-fat diet (HFD) mice (n = 5) for coronary flow (a), left ventricle developed pressure (LVDP, b), and heart rate (HR, c). Values are mean ± SEM. *Significant difference vs. concentration response curve in WT or ApoE KO by two-way ANOVA (P < 0.05)