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. 2017 Nov 30;8:1671. doi: 10.3389/fimmu.2017.01671

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Copyright © 2017 Xue, Zhang, Chen, Lu, Deng and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DC-single immunoglobulin IL-1-related receptor (SIGIRR) molecule reduced the populations of Th1 and Th17 cells and their secreted cytokines while increased the IL-10 level and induced expansion of Treg in transplant recipients. (A–C) Representative flow cytometry plots showing quantity of Th1, Th17, and Treg lymphocytes in draining lymph nodes and spleens of PBS control, Ad-DC, and DC-SIGIRR on day 10 after transplantation and on the day of rejection. (D) Cytokines level of serum were analyzed on day 10 after transplantation and on the day of rejection. Data represent the mean ± SD of three independent experiments. *P < 0.05, n = 5.