Table 2.
Fold-change differential expression of histamine-related genes in motor cortex and spinal cord of sporadic ALS (sALS) patients.
| Gene symbol | Motor cortex | Motor cortex | Spinal cord | Spinal cord |
|---|---|---|---|---|
| sALS1/control | sALS2/control | sALS1/control | sALS2/control | |
| ADCY1 | – | 2.43 | – | – |
| ADCY2 | 3.11 | – | – | 1.66 |
| ADCY3 | – | −3.57 | – | – |
| ADCY6 | 1.85 | – | – | – |
| ADCY9 | – | 9.54 | – | 2.87 |
| AOC1 | – | 2.79 | – | 1.54 |
| CREB1 | – | 9.41 | – | 2.75 |
| CREM | 1.64 | −1.65 | – | – |
| GNA11 | 2.08 | – | – | – |
| GNAI1 | – | −2.25 | – | – |
| GNAOl | 1.98 | −3.87 | 2.09 | – |
| GNAQ | 2.51 | −0.54 | – | – |
| GNAS | – | −0.35 | −1.75 | −1.73 |
| GNAZ | – | −2.15 | – | – |
| GNB1 | – | −3.53 | – | – |
| GNB2 | 1.93 | 2.35 | – | – |
| GNB4 | – | −2.29 | −1.57 | – |
| GNG10 | – | −2.95 | −1.51 | – |
| GNG11 | – | −2.93 | −1.66 | – |
| GNG13 | – | −2.95 | – | −1.59 |
| GNG3 | 3.42 | 2.97 | 4.55 | 2.65 |
| GNG4 | – | −2.21 | – | – |
| GNG5 | 1.85 | −1.72 | – | – |
| GNG7 | – | −3.13 | – | – |
| GNGT1 | −9.24 | 3.91 | 2.86 | 1.56 |
| HDC | – | 1.51 | – | – |
| HNMT | – | 2.62 | – | – |
| HRH1 | 1.96 | 4.20 | −1.37 | −3.37 |
| HRH2 | – | −1.74 | – | – |
| HRH3 | – | −3.46 | 3.31 | 3.24 |
| HRH4 | −1.51 | 2.03 | – | – |
| ICAM1 | – | 1.27 | – | – |
| IL10 | – | −2.72 | – | |
| IL12B | – | 1.93 | ||
| IL1B | – | −1.63 | ||
| IL6 | – | −2.23 | −1.57 | |
| ITPR1 | – | −5.07 | −1.55 | |
| MAP2K2 | – | −2.35 | ||
| MAPK1 | – | 0.05 | ||
| MMP1 | – | 3.10 | ||
| MMP13 | – | 7.53 | ||
| MMP9 | – | −3.45 | ||
| NFATC1 | 1.94 | – | ||
| NFATC2 | −2.45 | – | – | −1.66 |
| NFKB1 | – | −3.01 | −1.61 | −1.67 |
| NFKB2 | −1.48 | – | – | |
| NOS2 | – | −2.44 | ||
| PLCB1 | – | −5.76 | ||
| PLCB3 | – | 4.65 | 1.53 | |
| PRKACA | – | −0.36 | ||
| PRKACB | – | −4.34 | ||
| PRKAR1A | 2.32 | −3.24 | −1.81 | |
| PRKAR2A | – | −0.07 | −1.51 | |
| PRKAR2B | – | −1.81 | ||
| PRKCA | – | −0.97 | ||
| RAF1 | – | −1.40 | ||
| REL | 1.93 | 2.90 | ||
| RELA | −6.45 | −3.83 | – | −1.71 |
| RELB | 1.84 | – | ||
| TNF | −1.43 | – | ||
| VCAM1 | – | 3.93 | – | – |
The table lists the principal histamine-related genes differentially expressed in motor cortex and spinal cord of sALS patients (subgroups sALS1 and sALS2) in comparison with controls. Expression levels are indicated as fold-change values.