Table 7.
Common DE genes [FDR p-values (< 0.05), |Log2FC| >1.0] showing consistent directional change by treatment.
| 33R vs. 38R | 33F vs. 38F | 43R vs. 38R | 43F vs. 38F | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | Description | Log2FC | FDR pval | Log2FC | FDR pval | Log2FC | FDR pval | Log2FC | FDR pval |
| ABLIM2 | Actin binding LIM protein family, member 2 | −2.054 | 0.001493 | −1.390 | 0.004024 | 1.353 | 0.001549 | 1.418 | 4.88E-07 |
| LOC104912064 | Disintegrin and metalloproteinase domain-containing protein 12-like | −1.231 | 0.035684 | −1.447 | 0.000151 | 1.739 | 2.65E-07 | 1.573 | 9.79E-13 |
| APBA2 | Amyloid beta (A4) precursor protein-binding, family A, member 2 | −1.319 | 0.001841 | −1.274 | 7.45E-09 | 2.041 | 1.52E-20 | 1.135 | 1.5E-14 |
| ARHGAP28 | Rho GTPase activating protein 28 | −1.852 | 1.38E-05 | −1.690 | 2.9E-07 | 1.581 | 3.62E-06 | 1.145 | 6.23E-07 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | −1.356 | 0.001483 | −1.633 | 0.000236 | 1.193 | 0.000193 | 1.931 | 7.36E-16 |
| BCL6 | B-cell CLL/lymphoma 6 | −1.024 | 1.31E-06 | −1.079 | 8.27E-30 | 1.171 | 1.37E-09 | 1.177 | 1.3E-65 |
| C8H10orf71 | Chromosome 8 open reading frame, human C10orf71 | −2.257 | 2.07E-27 | −2.531 | 1.83E-83 | 1.786 | 3.24E-26 | 1.430 | 1.85E-50 |
| CDK18 | Cyclin-dependent kinase 18 | −2.219 | 3.25E-10 | −1.751 | 3.86E-11 | 1.300 | 4.65E-08 | 1.053 | 6.42E-09 |
| CHST1 | Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | −3.057 | 3.89E-06 | −3.571 | 7.87E-08 | 1.440 | 1.37E-05 | 1.722 | 1.83E-08 |
| COL3A1 | Collagen, type III, alpha 1 | −2.903 | 0 | −2.382 | 0 | 1.659 | 2.98E-12 | 1.923 | 1.18E-27 |
| COL4A1 | Collagen, type IV, alpha 1 | −1.606 | 5.48E-14 | −1.224 | 0 | 1.217 | 1.83E-08 | 1.685 | 1.24E-40 |
| DCX | Doublecortin | −2.199 | 4.6E-09 | −1.987 | 2.44E-19 | 1.815 | 3.08E-11 | 1.073 | 1.75E-14 |
| LOC104911002 | Dickkopf-related protein 3-like | −2.513 | 4.9E-08 | −1.496 | 9.78E-05 | 1.626 | 6.64E-10 | 1.797 | 3.55E-19 |
| LOC100540803 | Delta and Notch-like epidermal growth factor-related receptor | −2.602 | 0.003208 | −2.278 | 0.009568 | 1.750 | 6.59E-05 | 1.973 | 6.31E-07 |
| LOC100545932 | Dystrobrevin alpha | −1.700 | 0.004161 | −2.497 | 4.6E-06 | 1.703 | 1.34E-06 | 1.535 | 5.69E-08 |
| LOC104910320 | Dystrobrevin alpha-like | −2.452 | 0.000109 | −2.072 | 1.99E-05 | 1.320 | 0.00051 | 1.007 | 0.001196 |
| LOC104910337 | Dystrobrevin alpha-like | −2.896 | 0.028765 | −2.277 | 0.010759 | 2.334 | 1.68E-05 | 1.380 | 0.001723 |
| LOC100539830 | Dysferlin-like | −1.673 | 0.000158 | −1.487 | 0.001369 | 1.095 | 0.000961 | 1.553 | 3.96E-07 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | −1.772 | 0.001852 | −2.548 | 1.79E-08 | 2.296 | 6.27E-12 | 1.137 | 7.91E-06 |
| GNG2 | Guanine nucleotide binding protein (G protein), gamma 2 | −1.704 | 1.86E-06 | −1.474 | 2.75E-06 | 1.126 | 9.24E-06 | 1.158 | 4.56E-08 |
| GRIN2A | Glutamate receptor, ionotropic, N-methyl D-aspartate 2A | −2.471 | 4.6E-12 | −1.899 | 1.35E-14 | 1.115 | 1.98E-07 | 1.354 | 4.38E-22 |
| GUCA1B | Guanylate cyclase activator 1B (retina) | −3.228 | 2.28E-05 | −6.281 | 2.68E-05 | 2.990 | 1.44E-23 | 3.316 | 1.18E-25 |
| LOC104909294 | Hypermethylated in cancer 1 protein | −2.281 | 2.93E-05 | −3.489 | 6.51E-10 | 1.876 | 2.64E-09 | 2.233 | 1.28E-29 |
| LOC100541783 | Hypermethylated in cancer 1 protein-like | −1.977 | 0.027443 | −3.105 | 0.002499 | 2.380 | 3.83E-09 | 2.684 | 2.86E-15 |
| INHA | Inhibin, alpha | −5.346 | 1.21E-15 | −6.115 | 4.21E-20 | 1.205 | 2.72E-05 | 1.180 | 2.92E-07 |
| LOC100547979 | Junctophilin-1 | −4.175 | 1.97E-17 | −3.904 | 7.22E-23 | 2.198 | 2.21E-19 | 1.723 | 2.29E-23 |
| LOC104917153 | Small conductance calcium-activated potassium channel protein 3 | −1.103 | 0.027791 | −1.368 | 0.000591 | 1.241 | 0.000199 | 1.234 | 1.4E-06 |
| KLB | Klotho beta | −2.008 | 4.52E-14 | −2.114 | 1.07E-43 | 1.060 | 3.28E-07 | 1.049 | 1.72E-16 |
| KLHL31 | Kelch-like family member 31 | −2.298 | 4.77E-08 | −3.752 | 1.06E-19 | 2.070 | 1.16E-12 | 1.284 | 5.06E-08 |
| LEF1 | Lymphoid enhancer-binding factor 1 | −5.804 | 0.002693 | −4.107 | 0.00012 | 1.684 | 0.003038 | 1.957 | 1.61E-06 |
| LHFPL3 | Lipoma HMGIC fusion partner-like 3 | −1.892 | 0.001752 | −1.144 | 0.005348 | 1.391 | 0.000141 | 1.788 | 6.76E-14 |
| LOC104912085 | Uncharacterized LOC | −1.805 | 6.64E-11 | −1.791 | 3.01E-07 | 1.795 | 4.69E-15 | 1.270 | 5.13E-06 |
| LOC104914708 | Uncharacterized LOC | −3.041 | 4.19E-08 | −2.491 | 1.47E-16 | 1.414 | 8.5E-05 | 1.543 | 3.96E-23 |
| LTBP2 | Latent transforming growth factor beta binding protein 2 | −2.355 | 4.6E-44 | −2.465 | 4.81E-43 | 1.535 | 2.35E-24 | 1.854 | 5.97E-21 |
| LOC104909252 | Myosin-3-like | −6.600 | 1.56E-05 | −6.693 | 6.28E-07 | 1.071 | 0.039632 | 1.195 | 0.003104 |
| LOC100543020 | Myosin-7-like | −3.828 | 1.32E-05 | −3.409 | 0.000241 | 1.192 | 0.007426 | 1.221 | 0.004462 |
| LOC100549331 | Myosin-7-like | −5.467 | 4.06E-71 | −6.412 | 0 | 1.275 | 3.75E-06 | 1.390 | 6.35E-31 |
| LOC100544354 | Uncharacterized LOC | −5.397 | 0.014658 | −5.702 | 0.002833 | 1.954 | 0.002783 | 1.448 | 0.009527 |
| LOC104914128 | Uncharacterized LOC | −2.861 | 0.00076 | −3.030 | 1.8E-05 | 1.456 | 0.001195 | 1.698 | 7.65E-09 |
| NFATC2 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | −2.476 | 0.020677 | −2.123 | 0.003688 | 1.779 | 0.000711 | 1.675 | 2.65E-05 |
| OASL | 2′–5′-Oligoadenylate synthetase-like | −1.909 | 1.5E-08 | −1.554 | 4.62E-09 | 2.351 | 1.3E-29 | 2.333 | 7.81E-66 |
| OPCML | Opioid binding protein/cell adhesion molecule-like | −2.642 | 1.09E-11 | −1.680 | 1.43E-21 | 1.270 | 2.36E-06 | 2.338 | 5.65E-21 |
| P2RY1 | Purinergic receptor P2Y, G-protein coupled, 1 | −1.507 | 0.000988 | −1.140 | 0.013083 | 1.259 | 6.78E-05 | 1.932 | 6.03E-16 |
| PALMD | Palmdelphin | −2.571 | 3.06E-05 | −4.140 | 5.6E-09 | 1.568 | 5.2E-06 | 1.613 | 2.51E-08 |
| LOC104914006 | Receptor-type tyrosine-protein phosphatase T-like | −2.385 | 1.73E-12 | −2.643 | 2E-28 | 2.389 | 1.61E-33 | 1.880 | 5.84E-89 |
| LOC104914794 | Iporin-like | −1.551 | 3.48E-05 | −1.618 | 2.51E-10 | 1.509 | 9.48E-07 | 1.310 | 1.39E-12 |
| RYR1 | Ryanodine receptor 1 (skeletal) | −2.016 | 9.81E-05 | −2.523 | 0.000488 | 1.361 | 2.2E-05 | 1.894 | 1.47E-09 |
| LOC104916851 | Ryanodine receptor 1-like | −1.297 | 0.01007 | −2.003 | 7.49E-06 | 1.469 | 9.89E-06 | 1.875 | 1.34E-17 |
| LOC104917345 | Ryanodine receptor 1-like | −1.549 | 0.003033 | −1.727 | 0.00029 | 1.208 | 0.001046 | 1.777 | 3.21E-13 |
| LOC104913331 | Putative E3 ubiquitin-protein ligase SH3RF2 | −5.398 | 0.013363 | −6.023 | 0.000157 | 2.091 | 0.000434 | 1.132 | 0.035376 |
| SHROOM1 | Shroom family member 1 | −2.387 | 7.34E-07 | −2.096 | 3.88E-07 | 1.263 | 4.57E-05 | 1.482 | 7.73E-11 |
| LOC100546217 | protein TENP | −5.045 | 0.038689 | −4.947 | 0.043268 | 1.767 | 0.021551 | 3.304 | 1.16E-12 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | −1.582 | 0 | −1.683 | 0 | 1.690 | 5.37E-33 | 1.422 | 8.26E-31 |
| LOC100542775 | Alpha-2-macroglobulin-like protein 1 | 2.407 | 7.18E-09 | 2.252 | 2.22E-11 | −1.990 | 0.040101 | −2.381 | 0.00191 |
| C1QTNF4 | C1q and tumor necrosis factor related protein 4 | 1.106 | 1.2E-15 | 1.168 | 8.66E-38 | −1.107 | 2.2E-12 | −1.070 | 0 |
| CD36 | CD36 molecule (thrombospondin receptor) | 2.300 | 2.05E-46 | 2.479 | 9.79E-46 | −2.606 | 3.59E-17 | −2.131 | 3.52E-27 |
| CNDP1 | Carnosine dipeptidase 1 (metallopeptidase M20 family) | 1.117 | 0.007658 | 1.413 | 1.9E-05 | −3.750 | 1.16E-07 | −1.882 | 0.000797 |
| LOC100550279 | HLA class II histocompatibility antigen, DM beta chain-like | 1.627 | 4.24E-29 | 1.928 | 6.54E-50 | −1.339 | 0 | −2.694 | 2.97E-91 |
| ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3 | 1.002 | 0.012146 | 1.079 | 3.4E-05 | −1.395 | 0.005746 | −1.241 | 0.001609 |
| ESAM | Endothelial cell adhesion molecule | 1.958 | 1.42E-07 | 2.116 | 5.48E-25 | −1.339 | 0.012003 | −2.291 | 9.08E-08 |
| ETV7 | ets variant 7 | 2.160 | 2.67E-06 | 1.664 | 5.7E-08 | −2.342 | 0.003252 | −2.101 | 0.000492 |
| LOC104917139 | Germin-like protein subfamily 2 member 2 | 1.627 | 0.000198 | 1.141 | 6.34E-05 | −5.294 | 4.91E-09 | −3.698 | 1.06E-09 |
| LOC100539100 | Guanylate cyclase soluble subunit beta-2-like | 2.063 | 6.72E-21 | 1.708 | 2.8E-25 | −1.209 | 0.000197 | −1.081 | 4.92E-05 |
| LOC100543128 | Histone H3-like | 1.487 | 1.79E-07 | 1.169 | 1.34E-10 | −2.755 | 5.02E-09 | −2.480 | 2.18E-18 |
| IL18BP | Interleukin 18 binding protein | 1.513 | 0.000535 | 1.325 | 4.57E-06 | −2.087 | 0.000679 | −2.409 | 3.58E-06 |
| LOC104916207 | Kallikrein-8-like | 1.284 | 0.000119 | 1.215 | 6.35E-06 | −1.304 | 0.006723 | −1.537 | 0.000479 |
| LRAT | Lecithin retinol acyltransferase (phosphatidylcholine–retinol O-acyltransferase) | 1.219 | 1.27E-05 | 1.178 | 4.02E-10 | −1.302 | 0.000548 | −1.028 | 0.000202 |
| LOC100549167 | Mannose-binding protein A-like | 1.670 | 0.002909 | 1.232 | 0.010338 | −3.692 | 0.004571 | −3.695 | 0.00115 |
| MTNR1A | Melatonin receptor 1A | 1.515 | 0.000877 | 1.153 | 0.0135 | −2.098 | 0.009624 | −1.611 | 0.023993 |
| LOC104909506 | Uncharacterized LOC | 1.567 | 0.006758 | 1.695 | 5.46E-05 | −2.746 | 0.021177 | −2.932 | 0.002457 |
| LOC104910409 | Uncharacterized LOC | 1.067 | 0.003554 | 1.193 | 7.65E-05 | −2.385 | 7.52E-06 | −1.160 | 0.010109 |
| LOC104911590 | Uncharacterized LOC | 1.319 | 2.43E-06 | 1.103 | 9.54E-09 | −1.940 | 3.03E-07 | −2.072 | 8.46E-11 |
| LOC104912270 | Uncharacterized LOC | 1.400 | 3.32E-11 | 1.230 | 2.85E-15 | −1.335 | 6.18E-05 | −1.116 | 4.73E-08 |
| LOC104912544 | Uncharacterized LOC | 1.332 | 2.14E-05 | 1.304 | 8.93E-10 | −1.550 | 0.000542 | −1.963 | 2.5E-08 |
| LOC104913567 | Uncharacterized LOC | 1.240 | 1.61E-14 | 1.029 | 6.62E-35 | −1.328 | 2.57E-11 | −1.137 | 3.08E-26 |
| LOC104913826 | Uncharacterized LOC | 1.515 | 1.98E-22 | 1.564 | 4.58E-37 | −1.109 | 9.44E-07 | −1.104 | 5.72E-11 |
| LOC104914493 | uncharacterized LOC | 1.418 | 0.001313 | 1.516 | 5E-05 | −1.869 | 0.007214 | −2.320 | 0.002089 |
| NOXO1 | NADPH oxidase organizer 1 | 1.653 | 1.97E-10 | 1.357 | 7.28E-17 | −2.124 | 1.47E-09 | −1.591 | 6.04E-09 |
| NTSR1 | Neurotensin receptor 1 (high affinity) | 1.209 | 0.029619 | 1.309 | 0.001145 | −2.517 | 0.002856 | −2.140 | 0.004664 |
| PCBP3 | Poly(rC) binding protein 3 | 1.527 | 8.42E-09 | 1.406 | 8.33E-16 | −1.491 | 7.04E-05 | −1.521 | 4.59E-08 |
| PIGM | Phosphatidylinositol glycan anchor biosynthesis, class M | 1.107 | 0.000363 | 1.095 | 4.43E-07 | −1.324 | 0.000604 | −1.023 | 0.000899 |
| PLS1 | Plastin 1 | 1.251 | 2.14E-09 | 1.473 | 1.37E-32 | −2.179 | 3.22E-15 | −1.691 | 3.69E-20 |
| PTGR1 | Prostaglandin reductase 1 | 2.046 | 7.33E-09 | 2.261 | 2.27E-14 | −1.937 | 0.001524 | −2.169 | 0.00077 |
| RANBP17 | RAN binding protein 17 | 1.835 | 6.16E-08 | 1.038 | 5.8E-05 | −1.391 | 0.017844 | −2.861 | 8.69E-10 |
| SERPINF2 | Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 1.395 | 2.6E-16 | 1.163 | 1.15E-27 | −1.207 | 1.55E-08 | −1.096 | 1.28E-14 |
| SH2D4A | SH2 domain containing 4A | 1.314 | 6.2E-07 | 1.371 | 8.49E-13 | −1.828 | 2.37E-07 | −2.367 | 1.25E-11 |
| SH2D5 | SH2 domain containing 5 | 1.108 | 0.019073 | 1.063 | 0.00494 | −2.319 | 0.000812 | −1.171 | 0.030757 |
| SH3GLB2 | SH3-domain GRB2-like endophilin B2 | 1.380 | 5.63E-21 | 1.065 | 1.78E-49 | −1.095 | 7.41E-11 | −1.345 | 3.32E-40 |
| LOC104915044 | spErm-associated antigen 4 protein-like | 2.185 | 2.89E-06 | 1.644 | 1.1E–05 | −3.967 | 0.000862 | −2.010 | 0.007625 |
Comparisons highlighted red are up regulated in the comparison whereas genes highlighted in green are down regulated.