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. 2017 Dec 4;7:16898. doi: 10.1038/s41598-017-16318-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations of metabolite/Cr ratios with BMI. IMCL13/Cr (a), IMCL21/Cr (b), EMCL11/Cr (c), EMCL15/Cr (d), and tau/Cr (e) plotted versus the body mass index (BMI) of the healthy volunteers. Data points that were excluded from analysis are shown as open circles. Linear regressions are displayed as red lines, and Pearson regression coefficients, r, and significance values, p, are given for each data set. It can be seen (b) that the IMCL21/Cr ratio correlates significantly with BMI. Although not statistically significant, the other metabolite/Cr ratios shown here do exhibit a strong positive correlation with BMI, suggesting that not only unsaturated bonds in IMCL fatty acids (IMCL21) are increased at high BMIs, but also the number of lipid molecules in EMCL, the number of saturated bonds in fatty acids of both compartments, as well as taurine. Other metabolite/Cr ratios that do not show a strong correlation with BMI can be found in the supporting information (Fig. S5.1).