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. 2017 Oct 20;8:1078. doi: 10.1038/s41467-017-01125-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Characterization of heterogeneous 3D cardiac tissue sheets (CTSs). a Representative confocal microscopic image of a whole CTS that was immunostained for cTnT (cardiomyocytes, red), CD90 (mesenchymal cells, green), and DAPI (nuclei, blue). b High-magnification image of a horizontal cross-section (see Supplementary Movie 1). cTnT (red), CD90 (green), and DAPI (blue). c Confocal immunostaining of a vertical cross-section. cTnT (red), CD90 (green), and DAPI (blue). d Confocal immunostaining of a vertical cross-section. DAPI (white). e Macroscopic appearance of a CTS set on a multi-electrode array probe. Arrow: CTS. Black arrowhead: a reference electrode (four reference electrodes in total). White arrowhead: main electrodes (multi-electrode array). f Representative EFP waveforms obtained from each electrode. g Representative electrical propagation map. Propagation from the lower left corner towards the upper right direction. cTnT, cardiac troponin-T; DAPI, 4′,6-diamidino-2-phenylindole. Scale bars: 25 μm in b, 50 μm in c, d, and 1 mm in e