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. 2017 Oct 20;8:1078. doi: 10.1038/s41467-017-01125-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Drug-induced TdP-like EFP waveforms in CTSs. a EFP waveforms in response to E-4031 (IKr channel blocker). b Overlaid EFP waveforms at each E-4031 dosage. FPD prolongation is observed. c Relative change in FPD after E-4031 treatment (±s.d., n = 4). d Representative transient change of EFP waveforms at an early stage after E-4031 treatment (1 μM). e Representative monomorphic ventricular tachycardia-like waveform after E-4031 treatment (1 μM). f Representative polymorphic ventricular tachycardia TdP-like waveform after E-4031 treatment (1 μM)