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. 2017 Dec 4;7:16887. doi: 10.1038/s41598-017-17177-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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An example of a small-scale pre-clinical drug screen with the TNBC breast cancer cell line MDA-MB-231, invading into organotypic matrices and treated for 7 days with either control (DMSO), Y-27632 (10 μM) or Gefitinib (100 nM). Representative images are given for (a) pan-cytokeratin staining, which was (b) scored for invasion depth (n = 4). Representative images are also given for (c) Ki67 staining, which was (d) scored for proliferation (n = 4). Scale bars: 100 μm. Scale bars (insets): 12.5 μm. Mean ± SEM.