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. 2017 Dec 4;7:16890. doi: 10.1038/s41598-017-17322-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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WGCNA derived modules of gene expression. (a) An overall view of the network of gene expression. Height on the y-axes represents the dissimilarity of detected transcripts from the overall topology of gene expression. Colors below each line show the modules to which each transcript was assigned. (b) The eigengenes for each module are enriched for specific biological processes. For each module, we performed gene ontology (GO) enrichment, listing the term.id and name for each module (see also supplementary file 4 for p values). The module eigengenes showed correlation with each other, as indicated in the heatmap on the right. (c,d) Examples of modules enriched for biological terms. We used cytoscape to visualize organization of genes assigned to the GO category mitochondria organization in the cyan module (c) or the GO category ‘ensheathment of neurons’ in the red module (d). Circles are sized by the within module connectivity (Kwithin).