Table 1.
Summary of eight candidate STRs.
| STR | Locia | Tumor expressionb | (anti)-androgen regulationc in LNCaP cells | Alleles |
|---|---|---|---|---|
| TAAA-ACTG2 | chr2:74144316–74144336 | Down | Not expressed | 5, 6 |
| GAAA-GRHL2 | chr8:102563848–102563874 | No change | Not regulated | 4, 5 |
| TTTTG-TRIB1 | chr8:126450287–126450311 | Up | DHT (↓) | 3, 4, 5 |
| TTTTTG-PRUNE2 | chr9:79395653–79395679 | Up | Not assessed | Not polymorphic |
| TG-PCA3 | chr9:79400650–79400676 | Up | Enzalutamide (↓) | 9, 10, 11, 12, 13 |
| TG-GSN | chr9:124094978–124094997 | No change | Not assessed | Not genotyped |
| CAAAA-MXI1 | chr10:112044843–112044867 | No change | Enzalutamide (↓), DHT (↓) | 4, 5 |
| GAAA-PTGIS | chr20:48121708–48121728 | Down | Not assessed | Not polymorphic |
aRepeat Masker coordinate (hg19). bRT-qPCR validated expression in at least four of seven tumors with over 2-fold change in expression. c↓Indicates down-regulation by the respective (anti)-androgen. STR loci locations, their respective expression in tumor and in (anti)-androgen LNCaP cells and predicted number of repeats.