Table 1.
Summary of the sensitivity of ID8 clones to rucaparib and platinum.
| Genotype | Rucaparib IC50 (µM) mean +/− sd | p= | Cisplatin IC50 (µM) mean +/− sd | p= |
|---|---|---|---|---|
| Trp53 −/− | 8.23 +/− 0.62 | — | 1.10 +/− 0.47 | — |
| Trp53 −/−;Brca1 −/− | 0.24 +/− 0.21 | <0.01 | 0.38 +/− 0.22 | <0.0001 |
| Trp53 −/−;Brca2 −/− | 0.25 +/− 0.08 | <0.01 | 0.18 +/− 0.03 | <0.0001 |
| Trp53 −/−;Pten −/− | 11.2 +/− 6.94 | NS | 0.89 +/− 0.21 | NS |
| Trp53 −/−;Nf1 −/− | 4.31 +/− 1.33 | NS | 0.90 +/− 0.35 | NS |
| Trp53 −/−;Brca2 −/−;Pten −/− | 0.33 +/− 0.12 | <0.01 | 0.28 +/− 0.10 | <0.0001 |
Data represent IC50 averages from 4–8 triplicate experiments per cell line. IC50 values were compared using one-way ANOVA with Bonferroni’s test for multiple comparisons with Trp53 −/− cells as comparator.