Fig. 7.

Intercellular adhesion forces level in ZO-1/ZO-2 dKD polarized monolayers are regulated and maintained close to controls. a Model of the arrangement of intercellular actomyosin contractile pulling forces and intercellular adhesion forces at a cell–cell contact. The actomyosin pulling forces at tricellular juctions f _i depends on the level of epithelial tension and the length of the cell edge. The intercellular adhesion forces maintain epithelium cohesiveness and depend on actomyosin the level of the pulling forces (f _i), cell edge length (l _i), and cell edge angle (θ _i). b Intercellular normal and c shear adhesive forces determined on control and ZO-1/ZO-2 dKD polarized epithelial. * indicates significant difference in comparison with control P < 0.05(unpaired two-tailed Student’s t-test with Welch’s correction); NS nonsignificant differences in comparison with control P > 0.05(unpaired two-tailed Student’s t-test with Welch’s correction); number of measurements pooled for each condition, n = 14