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. 2017 Dec 4;7:16829. doi: 10.1038/s41598-017-16978-y

Figure 4.

Figure 4

Filtration method for mRNA targets of the 74 differentially expressed miRNAs in tumor vs normal adjacent tissues from Lebanese patients using IPA. 13202 mRNA targets were predicted as potential targets of 74 dysregulated miRNA in Lebanese samples. The predicted miRNA targets decreased to 1047 mRNAs after miRNA-mRNA integration, and then to 907 mRNAs when specifying breast tissue. mRNAs were filtered to 719 when choosing an inverse correlation of mRNA and miRNA expression. 719 mRNA are involved in decreasing cell movement, invasion, and metastasis as well as increasing proliferation, growth and cell cycle progression.