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. 2017 Dec 4;7:16907. doi: 10.1038/s41598-017-16964-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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QQplot showed SNPs associated with nicotine dependence are enriched for small p values in lung function GWAS. The y axis of the plot of the top row (plot A, B, C and D) denotes the observed p value of smoking adjusted FEV₁ in UKBB study; the y axis of the plot of the middle row (plot E, F, G and H) denotes the observed p value of smoking adjusted FVC in UKBB study; the y axis of the plot of the bottom row (plot I, J, K and L) denotes the observed p value of smoking adjusted FEV₁/FVC Ratio in UKBB study. In the 1st column (plot A, E and I), we investigated on SNPs associated with cigarettes per day (CPD) at ≤1e-2 (red dots), ≤1e-3 (blue dots), ≤1e-4 (green dots), and ≤1e-5 (black dots); in the 2nd column (plot B, F and J), we investigated on SNPs associated with ever smoking (EVERSMK) at ≤1e-2 (red dots), ≤1e-3 (blue dots), ≤1e-4 (green dots), and ≤1e-5 (black dots); in the 3rd column (plot C, G and K), we investigated on SNPs associated with former smoking (FORMER) at ≤1e-2 (red dots), ≤1e-3 (blue dots), ≤1e-4 (green dots), and ≤1e-5 (black dots); in the 4th column (plot D, H and L), we investigated on SNPs associated with log of smoking onset (ONSET) at ≤1e-2 (red dots), ≤1e-3 (blue dots), ≤1e-4 (green dots), and ≤1e-5 (black dots).