Table 3.
Polygenic score of nicotine dependence is associated with COPD case/control status adjusted for smoking duration
| PGS Training Trait | 1e-3 p-value threshold in PGS construction | 1e-4 p-value threshold in PGS construction | ||||
|---|---|---|---|---|---|---|
| # SNPs | β | p.value | # SNPs | β | p.value | |
| Cigarettes Per Day | 891 | 0.085 | 0.0376 | 116 | 0.197 | 1.82E-06 |
| Ever Smoked | 1110 | 0.072 | 0.070447 | 142 | 0.057 | 0.163214 |
| Former Smoker | 858 | −0.132 | 9.46E-04 | 114 | −0.067 | 0.106736 |
| LogOnset | 797 | 0.022 | 0.555505 | 76 | −0.019 | 0.544609 |
Polygenic score (PGS) formulation is established based on TAG GWAS summary data using 1e-3 and 1e-4 p value threshold on nicotine dependence (ND) traits. The ND PGS was computed on COPDgene dataset (sample size = 4903), and tested for association with COPD case-control status, adjusted for smoking duration. #SNPs, the number of SNPs used in PGS computation, β, association coefficient (ie, log Odds Ratio).