Table 3.

Association between age, gender and white matter microstructural measures.

		N	Mean (SD)	Age			Gender(female)			Age × Gender
				B	SE	η2	B	SE	η2	B	SE	η2
CEREBRUM
FA	NAWM	197	3.3 × 10−1(1.5x10−2)	−0.041**	0.014	0.040	−0.201	0.147	0.009
	WMH	200	2.7 × 10−1(3.3 × 10−2)	0.031*	0.014	0.022	−0.261	0.146	0.015
MD	NAWM	196	8.1 × 10−4(2.8 × 10−5)	0.100**¶	0.013	0.235	−0.073	0.130	0.001
	WMH	197	1.3 × 10−3(1.3 × 10−4)	−0.002	0.015	< 0.001	0.130	0.149	0.004
FRONTAL
FA	NAWM	197	3.3 × 10−1(1.5 × 10−2)	−0.047**¶	0.014	0.052	−0.188	0.146	0.008
	WMH	198	2.2 × 10−1(3.0 × 10−2)	0.049**¶	0.014	0.057	−0.156	0.143	0.006
MD	NAWM	196	8.3 × 10−4(3.2 × 10−5)	0.102**¶	0.013	0.244	0.008	0.129	< 0.001
	WMH	199	1.4 × 10−3(1.8 × 10−4)	−0.017	0.015	0.007	−0.106	0.148	0.003
PARIETAL
FA	NAWM	198	3.5 × 10−1(1.9 × 10−2)	−0.033*	0.014	0.026	−0.284	0.147	0.018
	WMH	196	3.3 × 10−1(5.3 × 10−2)	0.003	0.021	< 0.001	−4.198*	2.064	0.021	0.059*	0.029	0.020
MD	NAWM	196	7.9 × 10−4(2.2 × 10−5)	0.086**¶	0.013	0.175	0.085	0.136	0.002
	WMH	195	1.3 × 10−3(1.7 × 10−4)	−0.017	0.015	0.006	0.163	0.149	0.006
TEMPORAL
FA	NAWM	198	3.3 × 10−1(1.8 × 10−2)	−0.040**	0.014	0.038	0.072	0.147	0.001
	WMH	189	3.3 × 10−1(6.7 × 10−2)	0.059**¶	0.015	0.080	−0.097	0.146	0.002
MD	NAWM	196	8.2 × 10−4(2.9 × 10−5)	0.102**¶	0.020	0.109	3.504	1.899	0.014	−0.057*	0.027	0.018
	WMH	189	1.3 × 10−3(1.7 × 10−4)	−0.022	0.015	0.011	0.104	0.151	0.003
OCCIPITAL
FA	NAWM	198	2.6 × 10−1(1.6 × 10−2)	−0.032*	0.015	0.024	−0.172	0.147	0.007
	WMH	197	3.3 × 10−1(3.7 × 10−2)	0.001	0.015	< 0.001	0.130	0.150	0.004
MD	NAWM	197	7.9 × 10−4(3.1 × 10−4)	0.113**¶	0.019	0.146	3.932*	1.848	0.018	−0.058*	0.026	0.020
	WMH	197	1.1 × 10−3(1.2 × 10−4)	0.057**¶	0.014	0.076	−0.024	0.145	< 0.001

FA, fractional anisotropy; MD, mean diffusivity; NAWM, normal appearing white matter; SD, standard deviation; SE, standard error; WMH, white matter hyperintensity.

^*p < 0.05;

^**p < 0.01;

^¶corrected for multiple comparisons.

All models were adjusted for education, and diastolic blood pressure.