Table 4.

Differences in white matter characteristics between cerebral lobes.

		Frontal vs. Parietal	Frontal vs. Temporal	Frontal vs. Occipital	Parietal vs. Temporal	Parietal vs. Occipital	Temporal vs. Occipital
NAWM
FAb	Contrast	−0.014	0.013	0.085**¶	0.026	0.100**¶	0.072**¶
	SE	0.016	0.016	0.016	0.016	0.016	0.016
	χ2	0.69	0.61	27.03	2.60	36.31	19.40
	ϕ	0.030	0.028	0.185	0.057	0.214	0.157
	p	0.406	0.434	<0.001	0.107	<0.001	<0.001
MDb	Contrast	2.4 × 10−5	−3.3 × 10−5	−2.1 × 10−5	−5.7 × 10−5*	−4.5 × 10−5	1.2 × 10−5
	SE	2.9 × 10−5	2.9 × 10−5	2.9 × 10−5	2.9 × 10−5	2.9 × 10−5	2.9 × 10−5
	χ2	0.72	1.28	0.53	3.90	2.49	0.16
	ϕ	0.030	0.040	0.026	0.070	0.056	0.014
	p	0.396	0.258	0.465	0.048	0.114	0.685
WMH
Vol.a,b	Contrast	3.369*	1.639	−0.444	−1.730	−3.812*	−2.082
	SE	1.621	1.636	1.615	1.645	1.625	1.632
	χ2	4.32	1.00	0.08	1.11	5.50	1.63
	ϕ	0.075	0.036	0.010	0.038	0.085	0.046
	p	0.038	0.317	0.784	0.293	0.019	0.202
FAb	Contrast	−0.065	0.113	−0.172*	0.0178*	−0.108	−0.285**¶
	SE	0.077	0.079	0.077	0.079	0.077	0.079
	χ2	0.70	2.07	4.98	5.09	1.94	13.16
	ϕ	0.030	0.051	0.080	0.081	0.050	0.130
	p	0.403	0.150	0.026	0.024	0.164	<0.001
MDb	Contrast	1.4 × 10−4	3.2 × 10	1.2 × 10−3**¶	1.9 × 10−4	1.1 × 10−3**¶	8.8 × 10−4**¶
	SE	2.5 × 10−4	2.6 × 10−4	2.6 × 10−4	2.6 × 10−4	2.6 × 10−4	2.6 × 10−4
	χ2	0.28	1.55	22.06	0.52	17.28	11.45
	ϕ	0.019	0.045	0.168	0.026	0.149	0.121
	p	0.595	0.213	<0.001	0.471	<0.001	<0.001

FA, fractional anisotropy; MD, mean diffusivity; NAWM, normal appearing white matter; SE, standard error; Vol., volume; WMH, white matter hyperintensity.

^*p < 0.05;

^**p < 0.01;

^¶corrected for multiple comparisons.

^aNatural log transformed and divided by ICV.

^bAdjusted for age, gender, education, and blood pressure.