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. 2017 Oct 25;108(12):2352–2357. doi: 10.1111/cas.13407

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Ascites‐derived tumor cells are tumorigenic and patient‐derived xenografts mirror patient response to therapy in a 62‐year‐old woman with endometrial cancer and breast cancer. (a) Ascites‐derived tumor cells enriched from the patient were injected into NOD/SCID mice. Representative images of H&E staining are shown. (b,c) Representative images of immunohistochemistry staining in primary endometrial cancer (b) and the patient‐derived xenograft model (c). CA125, cancer antigen 125; CK8, cytokeratin 8; PTEN, phosphatase and tensin homolog; WT1, Wilms’ tumor suppressor gene 1. (d) Prominent central necrosis in the treated group and immunohistochemistry staining of anti‐Ki67.