Table 3.
Epidemiological characteristics and comorbidities of Japanese patients with adult T‐cell leukemia–lymphoma, by disease subtype (n = 922)
| Characteristic | Total | Acute | Lymphoma | Chronic | Smoldering | P‐value |
|---|---|---|---|---|---|---|
| Total patients, n | 922 | 456 | 237 | 131 | 98 | |
| Male sex, n (% of each subtype) | 487 | 241 (52.9) | 141 (59.5) | 53 (40.5) | 52 (53.1) | 0.007 |
| Geographic area of hospitals, n (% of each subtype) | ||||||
| Hokkaido–Tohoku | 50 | 19 (38.0) | 15 (30.0) | 10 (20.0) | 6 (12.0) | 0.380 |
| Kanto | 59 | 28 (47.5) | 15 (25.4) | 8 (13.6) | 8 (13.6) | |
| Chubu–Hokuriku | 55 | 25 (45.4) | 22 (40.0) | 5 (9.1) | 3 (5.5) | |
| Kinki | 88 | 36 (40.9) | 25 (24.4) | 16 (18.2) | 11 (12.5) | |
| Chugoku–Shikoku | 48 | 24 (50.0) | 11 (22.9) | 6 (12.5) | 7 (14.6) | |
| Kyushu–Okinawa | 622 | 324 (52.1) | 149 (24.0) | 86 (13.8) | 63 (10.1) | |
| Age at diagnosis, years | ||||||
| Median (IQR) | 922 | 68 (61–75) | 70 (63–77) | 65 (57–73) | 67.5 (60–74) | <0.001 |
| Median (min, max) | 922 | 68 (34, 100) | 70 (37, 90) | 65 (36, 85) | 67.5 (40, 89) | <0.001 |
| Mean (SD) | 922 | 67.7 (11.1) | 69.6 (10.1) | 64.5 (11.0) | 66.0 (10.6) | <0.001 |
| Age category, years, n (% of each subtype) | ||||||
| <50 | 51 | 24 (5.2) | 8 (3.4) | 10 (7.6) | 9 (9.2) | 0.003 |
| 50–59 | 152 | 71 (15.6) | 33 (13.9) | 35 (26.7) | 13 (13.3) | |
| 60–69 | 307 | 161 (35.3) | 68 (28.7) | 41 (31.3) | 37 (37.7) | |
| 70–79 | 282 | 133 (29.2) | 85 (35.9) | 33 (25.2) | 31 (31.6) | |
| ≥80 | 130 | 67 (14.7) | 43 (16.1) | 12 (9.2) | 8 (8.2) | |
| Comorbidities, n (% of each subtype) | ||||||
| Any disease, yes | 297 | 145 (32.2) | 67 (28.5) | 43 (33.6) | 42 (43.8) | 0.060 |
| Hematological malignancies, yes | 8 | 4 (0.9) | 2 (0.8) | 0 (0.0) | 2 (2.0) | 0.440 |
| Non‐hematological malignancies, yes | 113 | 53 (11.6) | 21 (8.9) | 17 (13.0) | 22 (22.4) | 0.007 |
| Infectious diseases, yes | 93 | 53 (11.6) | 16 (6.8) | 14 (10.7) | 10 (10.2) | 0.250 |
| Neurologic diseases, yes | 21 | 13 (2.9) | 4 (1.7) | 3 (2.3) | 1 (1.0) | 0.630 |
| Autoimmune diseases, yes | 9 | 3 (0.7) | 1 (0.4) | 3 (2.3) | 2 (2.0) | 0.190 |
IQR, interquartile range; max, maximum; min, minimum.