Table 2.
Adverse events
| Adverse event | PPV plus herbal medicines (n = 31) | PPV alone (n = 35) | ||||||
|---|---|---|---|---|---|---|---|---|
| Total (%) | G1 | G2 | G3 | Total (%) | G1 | G2 | G3 | |
| Systemic symptoms | ||||||||
| Injection site reaction | 26 (84) | 24 | 2 | 0 | 25 (71) | 24 | 1 | 0 |
| Tumor pain | 3 (10) | 3 | 0 | 0 | 5 (14) | 2 | 3 | 0 |
| Appetite loss | 1 (3) | 1 | 0 | 0 | 8 (23) | 3 | 5 | 0 |
| Fever | 1 (3) | 1 | 0 | 0 | 4 (11) | 2 | 2 | 0 |
| Fatigue | 2 (6) | 2 | 0 | 0 | 3 (9) | 3 | 0 | 0 |
| Edema peripheral | 5 (16) | 3 | 2 | 0 | 1 (3) | 1 | 0 | 0 |
| Hematuria | 3 (10) | 1 | 2 | 0 | 3 (9) | 2 | 1 | 0 |
| Blood/bone marrow | ||||||||
| Lymphocytopenia | 7 (23) | 4 | 3 | 0 | 10 (29) | 6 | 4 | 0 |
| Anemia | 8 (26) | 1 | 4 | 3 | 7 (20) | 2 | 4 | 1 |
| Laboratory | ||||||||
| ALP increased | 10 (32) | 7 | 2 | 1 | 8 (23) | 4 | 1 | 3 |
| AST increased | 4 (13) | 2 | 2 | 0 | 2 (6) | 0 | 1 | 1 |
| ALT increased | 3 (10) | 2 | 1 | 0 | 5 (14) | 1 | 3 | 1 |
| Hypo‐albuminemia | 8 (26) | 8 | 0 | 0 | 11 (31) | 9 | 2 | 0 |
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; PPV, personalized peptide vaccination.