Figure 8.

Propofol treatment induced down-regulation of the Jagged1/Notch pathway in the cerebellum at P8. (A) Representative western blotting for the Jagged1 and Notch1 proteins from the cerebella in each group. (B) Densitometric quantification of Jagged1. Jagged1 protein levels in the Propofol (30 mg/kg)- and Propofol (60 mg/kg)-treated groups were significantly lower than in the vehicle-treated group. (C) Densitometric quantification of Notch. Notch1 protein levels in the Propofol (30 mg/kg)- and Propofol (60 mg/kg)-treated groups were significantly lower than in the vehicle-treated group. *P < 0.05 and **P < 0.01.